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BDBM50326237 CHEMBL1243075::N-{1-[3-(6-Methoxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-propyl]-piperidin-4-yl}-2-phenyl-acetamide

SMILES: COc1ccc2N(CCCN3CCC(CC3)NC(=O)Cc3ccccc3)C(=O)CCc2c1

InChI Key: InChIKey=UKRRWVUULVILFQ-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326237   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50326237
PNG
(CHEMBL1243075 | N-{1-[3-(6-Methoxy-2-oxo-3,4-dihyd...)
Show SMILES COc1ccc2N(CCCN3CCC(CC3)NC(=O)Cc3ccccc3)C(=O)CCc2c1
Show InChI InChI=1S/C26H33N3O3/c1-32-23-9-10-24-21(19-23)8-11-26(31)29(24)15-5-14-28-16-12-22(13-17-28)27-25(30)18-20-6-3-2-4-7-20/h2-4,6-7,9-10,19,22H,5,8,11-18H2,1H3,(H,27,30)
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Article
PubMed
n/an/an/an/a 560n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay

J Med Chem 53: 6386-97 (2010)


Article DOI: 10.1021/jm100697g
BindingDB Entry DOI: 10.7270/Q2765G9K
More data for this
Ligand-Target Pair