BDBM50326284 1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene::CHEMBL1243275
SMILES: Cc1cccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(s1)-c1ccc(F)cc1
InChI Key: InChIKey=LQCIKRNQMUFICQ-PFKOEMKTSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM50326284 (1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL | Assay Description Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint... | J Med Chem 53: 6355-60 (2010) Article DOI: 10.1021/jm100332n BindingDB Entry DOI: 10.7270/Q2V69JSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 2, facilitated glucose transporter member 1 (Rattus norvegicus) | BDBM50326284 (1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorop...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL | Assay Description Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation counting | J Med Chem 53: 6355-60 (2010) Article DOI: 10.1021/jm100332n BindingDB Entry DOI: 10.7270/Q2V69JSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human)) | BDBM50326284 (1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL | Assay Description Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint... | J Med Chem 53: 6355-60 (2010) Article DOI: 10.1021/jm100332n BindingDB Entry DOI: 10.7270/Q2V69JSS | |||||||||||
More data for this Ligand-Target Pair |