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SMILES: Cc1cc2NC(=O)C(=NC(=S)N(CC=C)CC=C)c2c(C)c1O

InChI Key: InChIKey=MTDYVCJCWISUMJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326490   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50326490
PNG
(1,1-diallyl-3-(5-hydroxy-4,6-dimethyl-2-oxoindolin...)
Show SMILES Cc1cc2NC(=O)C(=NC(=S)N(CC=C)CC=C)c2c(C)c1O |w:8.8|
Show InChI InChI=1S/C17H19N3O2S/c1-5-7-20(8-6-2)17(23)19-14-13-11(4)15(21)10(3)9-12(13)18-16(14)22/h5-6,9,21H,1-2,7-8H2,3-4H3,(H,18,19,22,23)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Vichem Chemie Research Ltd.

Curated by ChEMBL


Assay Description
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay

J Med Chem 53: 6758-62 (2010)


Article DOI: 10.1021/jm1004368
BindingDB Entry DOI: 10.7270/Q2F18ZZ5
More data for this
Ligand-Target Pair