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BDBM50326538 (R)-2-(3-(2-(2-hydroxy-2-(4-hydroxy-3-(methylsulfonamido)phenyl)ethylamino)-2-methylpropyl)phenyl)-N-((4'-hydroxybiphenyl-4-yl)methyl)acetamide::CHEMBL1240966

SMILES: CC(C)(Cc1cccc(CC(=O)NCc2ccc(cc2)-c2ccc(O)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1

InChI Key: InChIKey=YJWDSNSUCGERRI-YTTGMZPUSA-N

Data: 1 EC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326538   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-2 adrenergic receptor and beta-3 adrenergic receptor


(Homo sapiens (Human))
BDBM50326538
PNG
((R)-2-(3-(2-(2-hydroxy-2-(4-hydroxy-3-(methylsulfo...)
Show SMILES CC(C)(Cc1cccc(CC(=O)NCc2ccc(cc2)-c2ccc(O)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 |r|
Show InChI InChI=1S/C34H39N3O6S/c1-34(2,36-22-32(40)28-13-16-31(39)30(19-28)37-44(3,42)43)20-25-6-4-5-24(17-25)18-33(41)35-21-23-7-9-26(10-8-23)27-11-14-29(38)15-12-27/h4-17,19,32,36-40H,18,20-22H2,1-3H3,(H,35,41)/t32-/m0/s1
PDB
MMDB

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Article
PubMed
n/an/an/an/a 0.240n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate m...


J Med Chem 53: 6640-52 (2010)


Article DOI: 10.1021/jm1005989
BindingDB Entry DOI: 10.7270/Q2X0678R
More data for this
Ligand-Target Pair