BDBM50326615 2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimethoxybenzyl)-pyrrolo[2,3-d]pyrimidine::CHEMBL1254444

SMILES: COc1ccc(OC)c(Cc2cc3c(nc(N)nc3[nH]2)N(C)c2cccc(Br)c2)c1

InChI Key: InChIKey=MFHUUPOUXJRWOX-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50326615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50326615 (2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimetho...) Show SMILES COc1ccc(OC)c(Cc2cc3c(nc(N)nc3[nH]2)N(C)c2cccc(Br)c2)c1 Show InChI InChI=1S/C22H22BrN5O2/c1-28(16-6-4-5-14(23)11-16)21-18-12-15(25-20(18)26-22(24)27-21)9-13-10-17(29-2)7-8-19(13)30-3/h4-8,10-12H,9H2,1-3H3,(H3,24,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.44E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of EGFR expressed in human A431 cells				Bioorg Med Chem 18: 5261-73 (2010) Article DOI: 10.1016/j.bmc.2010.05.049 BindingDB Entry DOI: 10.7270/Q29Z95W6
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50326615 (2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimetho...) Show SMILES COc1ccc(OC)c(Cc2cc3c(nc(N)nc3[nH]2)N(C)c2cccc(Br)c2)c1 Show InChI InChI=1S/C22H22BrN5O2/c1-28(16-6-4-5-14(23)11-16)21-18-12-15(25-20(18)26-22(24)27-21)9-13-10-17(29-2)7-8-19(13)30-3/h4-8,10-12H,9H2,1-3H3,(H3,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta expressed in human A431 cells				Bioorg Med Chem 18: 5261-73 (2010) Article DOI: 10.1016/j.bmc.2010.05.049 BindingDB Entry DOI: 10.7270/Q29Z95W6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50326615 (2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimetho...) Show SMILES COc1ccc(OC)c(Cc2cc3c(nc(N)nc3[nH]2)N(C)c2cccc(Br)c2)c1 Show InChI InChI=1S/C22H22BrN5O2/c1-28(16-6-4-5-14(23)11-16)21-18-12-15(25-20(18)26-22(24)27-21)9-13-10-17(29-2)7-8-19(13)30-3/h4-8,10-12H,9H2,1-3H3,(H3,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 expressed in human A431 cells				Bioorg Med Chem 18: 5261-73 (2010) Article DOI: 10.1016/j.bmc.2010.05.049 BindingDB Entry DOI: 10.7270/Q29Z95W6
					More data for this Ligand-Target Pair