BDBM50326709 (R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-(4-(4-(pyridin-4-yl)piperazin-1-yl)phenyl)urea::CHEMBL1253497
SMILES: CCCN1c2ccccc2C(CCc2ccccc2)=N[C@@H](NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2ccncc2)C1=O
InChI Key: InChIKey=VLIFIGMDNURHMV-UMSFTDKQSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50326709 ((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells | J Med Chem 53: 5383-99 (2010) Article DOI: 10.1021/jm1000776 BindingDB Entry DOI: 10.7270/Q289162Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50326709 ((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human bradykinin B1 receptor | J Med Chem 46: 1803-6 (2003) Article DOI: 10.1021/jm034020y BindingDB Entry DOI: 10.7270/Q29P32C6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDKRB1 (RAT) | BDBM50326709 ((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Binding affinity to rat bradykinin B1 receptor | J Med Chem 53: 5383-99 (2010) Article DOI: 10.1021/jm1000776 BindingDB Entry DOI: 10.7270/Q289162Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDKRB1 (RAT) | BDBM50326709 ((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Compound was tested for inhibition against rat Bradykinin receptor B1 | J Med Chem 46: 1803-6 (2003) Article DOI: 10.1021/jm034020y BindingDB Entry DOI: 10.7270/Q29P32C6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50326709 ((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation | J Med Chem 53: 5383-99 (2010) Article DOI: 10.1021/jm1000776 BindingDB Entry DOI: 10.7270/Q289162Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50326709 ((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay | J Med Chem 46: 1803-6 (2003) Article DOI: 10.1021/jm034020y BindingDB Entry DOI: 10.7270/Q29P32C6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDKRB1 (RAT) | BDBM50326709 ((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assay | J Med Chem 46: 1803-6 (2003) Article DOI: 10.1021/jm034020y BindingDB Entry DOI: 10.7270/Q29P32C6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDKRB1 (RAT) | BDBM50326709 ((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of rat bradykinin B1 receptor | J Med Chem 53: 5383-99 (2010) Article DOI: 10.1021/jm1000776 BindingDB Entry DOI: 10.7270/Q289162Z | |||||||||||
More data for this Ligand-Target Pair |