BDBM50326940 1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-pyrazolo[1,5-a]pyridin-2-ylmethylpentan-2-ol::CHEMBL1255079

SMILES: COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccccn2n1)C(F)(F)F

InChI Key: InChIKey=HGZWFFDLJPIVDH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50326940   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50326940 (1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...) Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccccn2n1)C(F)(F)F Show InChI InChI=1S/C21H22F4N2O2/c1-19(2,17-10-14(22)7-8-18(17)29-3)13-20(28,21(23,24)25)12-15-11-16-6-4-5-9-27(16)26-15/h4-11,28H,12-13H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50326940 (1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...) Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccccn2n1)C(F)(F)F Show InChI InChI=1S/C21H22F4N2O2/c1-19(2,17-10-14(22)7-8-18(17)29-3)13-20(28,21(23,24)25)12-15-11-16-6-4-5-9-27(16)26-15/h4-11,28H,12-13H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISA				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50326940 (1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...) Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccccn2n1)C(F)(F)F Show InChI InChI=1S/C21H22F4N2O2/c1-19(2,17-10-14(22)7-8-18(17)29-3)13-20(28,21(23,24)25)12-15-11-16-6-4-5-9-27(16)26-15/h4-11,28H,12-13H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to mineralocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by flu...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50326940 (1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...) Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2ccccn2n1)C(F)(F)F Show InChI InChI=1S/C21H22F4N2O2/c1-19(2,17-10-14(22)7-8-18(17)29-3)13-20(28,21(23,24)25)12-15-11-16-6-4-5-9-27(16)26-15/h4-11,28H,12-13H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to progesterone receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled RU-486 by fluorescence po...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair