BDBM50326953 1,1,1-Trifluoro-4-(3-fluorophenyl)-4-methyl-2-(1H-pyrrolo[2,3-c]-pyridin-2-ylmethyl)pentan-2-ol::CHEMBL1253987

SMILES: CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cccc(F)c1

InChI Key: InChIKey=ANPFZNKOHNLVIS-UHFFFAOYSA-N

Data: 4 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50326953   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50326953 (1,1,1-Trifluoro-4-(3-fluorophenyl)-4-methyl-2-(1H-...) Show SMILES CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cccc(F)c1 Show InChI InChI=1S/C20H20F4N2O/c1-18(2,14-4-3-5-15(21)9-14)12-19(27,20(22,23)24)10-16-8-13-6-7-25-11-17(13)26-16/h3-9,11,26-27H,10,12H2,1-2H3	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50326953 (1,1,1-Trifluoro-4-(3-fluorophenyl)-4-methyl-2-(1H-...) Show SMILES CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cccc(F)c1 Show InChI InChI=1S/C20H20F4N2O/c1-18(2,14-4-3-5-15(21)9-14)12-19(27,20(22,23)24)10-16-8-13-6-7-25-11-17(13)26-16/h3-9,11,26-27H,10,12H2,1-2H3	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to progesterone receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled RU-486 by fluorescence po...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50326953 (1,1,1-Trifluoro-4-(3-fluorophenyl)-4-methyl-2-(1H-...) Show SMILES CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cccc(F)c1 Show InChI InChI=1S/C20H20F4N2O/c1-18(2,14-4-3-5-15(21)9-14)12-19(27,20(22,23)24)10-16-8-13-6-7-25-11-17(13)26-16/h3-9,11,26-27H,10,12H2,1-2H3	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Transactivation activity at glucocorticoid receptor in HFF assessed as induction of aromatase activity after 18 to 24 hrs by ELISA				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50326953 (1,1,1-Trifluoro-4-(3-fluorophenyl)-4-methyl-2-(1H-...) Show SMILES CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cccc(F)c1 Show InChI InChI=1S/C20H20F4N2O/c1-18(2,14-4-3-5-15(21)9-14)12-19(27,20(22,23)24)10-16-8-13-6-7-25-11-17(13)26-16/h3-9,11,26-27H,10,12H2,1-2H3	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to mineralocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by flu...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50326953 (1,1,1-Trifluoro-4-(3-fluorophenyl)-4-methyl-2-(1H-...) Show SMILES CC(C)(CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)c1cccc(F)c1 Show InChI InChI=1S/C20H20F4N2O/c1-18(2,14-4-3-5-15(21)9-14)12-19(27,20(22,23)24)10-16-8-13-6-7-25-11-17(13)26-16/h3-9,11,26-27H,10,12H2,1-2H3	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISA				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair