BDBM50326988 3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one::CHEMBL69679::Zatebradine
SMILES: COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
InChI Key: InChIKey=KEDQCFRVSHYKLR-UHFFFAOYSA-N
Data: 3 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Mus musculus) | BDBM50326988 (3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 1.68E+4 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL | Assay Description Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay | J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Homo sapiens (Human)) | BDBM50326988 (3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 8.57E+3 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL | Assay Description Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay | J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus) | BDBM50326988 (3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 5.45E+3 | n/a | n/a | n/a | n/a |
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL | Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay | J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J | |||||||||||
More data for this Ligand-Target Pair |