BDBM50327019 CHEMBL1255004::N-Ethyl-4-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide

SMILES: CCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)Nc3ccon3)c2c1C

InChI Key: InChIKey=BFRAWBHWHWZWLT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327019   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50327019 (CHEMBL1255004 | N-Ethyl-4-(5-(isoxazol-3-ylcarbamo...) Show SMILES CCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)Nc3ccon3)c2c1C Show InChI InChI=1S/C21H21N7O3/c1-4-22-21(30)15-10-28-18(13(15)3)19(23-11-24-28)25-16-9-14(6-5-12(16)2)20(29)26-17-7-8-31-27-17/h5-11H,4H2,1-3H3,(H,22,30)(H,23,24,25)(H,26,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 mins				J Med Chem 53: 6629-39 (2010) Article DOI: 10.1021/jm100540x BindingDB Entry DOI: 10.7270/Q2JM29T1
					More data for this Ligand-Target Pair