BDBM50327069 1-[4-(5,6-Dihydro-4H-pyrrolo[3,2,1-de]pteridin-4-yl)-phenyl]-3-[3-(trifluoromethyl)phenyl]urea::CHEMBL1254096
SMILES: FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)N2CCn3ccc4ncnc2c34)c1
InChI Key: InChIKey=JCVWBFLIKUPNPW-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50327069 (1-[4-(5,6-Dihydro-4H-pyrrolo[3,2,1-de]pteridin-4-y...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of human VEGFR2 | Bioorg Med Chem 18: 7260-73 (2010) Article DOI: 10.1016/j.bmc.2010.08.017 BindingDB Entry DOI: 10.7270/Q2NC61DC | |||||||||||
More data for this Ligand-Target Pair |