BDBM50327271 CHEMBL1258961::endo-3-(8-(1-phenylcyclopropyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide

SMILES: NC(=O)c1cccc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C2(CC2)c2ccccc2)c1

InChI Key: InChIKey=DFAQDDJMQNABPJ-CEQLMSFQSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50327271   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50327271 (CHEMBL1258961 | endo-3-(8-(1-phenylcyclopropyl)-8-...) Show SMILES NC(=O)c1cccc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C2(CC2)c2ccccc2)c1 |r,TLB:17:16:9.15.10:13.12| Show InChI InChI=1S/C23H26N2O2/c24-22(26)16-5-4-8-20(13-16)27-21-14-18-9-10-19(15-21)25(18)23(11-12-23)17-6-2-1-3-7-17/h1-8,13,18-19,21H,9-12,14-15H2,(H2,24,26)/t18-,19+,21-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50327271 (CHEMBL1258961 | endo-3-(8-(1-phenylcyclopropyl)-8-...) Show SMILES NC(=O)c1cccc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C2(CC2)c2ccccc2)c1 |r,TLB:17:16:9.15.10:13.12| Show InChI InChI=1S/C23H26N2O2/c24-22(26)16-5-4-8-20(13-16)27-21-14-18-9-10-19(15-21)25(18)23(11-12-23)17-6-2-1-3-7-17/h1-8,13,18-19,21H,9-12,14-15H2,(H2,24,26)/t18-,19+,21-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human ERG				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50327271 (CHEMBL1258961 | endo-3-(8-(1-phenylcyclopropyl)-8-...) Show SMILES NC(=O)c1cccc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C2(CC2)c2ccccc2)c1 |r,TLB:17:16:9.15.10:13.12| Show InChI InChI=1S/C23H26N2O2/c24-22(26)16-5-4-8-20(13-16)27-21-14-18-9-10-19(15-21)25(18)23(11-12-23)17-6-2-1-3-7-17/h1-8,13,18-19,21H,9-12,14-15H2,(H2,24,26)/t18-,19+,21-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair