BDBM50327272 CHEMBL1258962::endo-3-(8-(1-(pyridin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide

SMILES: CC(N1[C@H]2CC[C@@H]1C[C@H](C2)Oc1cccc(c1)C(N)=O)c1ccncc1

InChI Key: InChIKey=MUZLNSIUFMZLMA-FLKAPXIRSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50327272   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50327272 (CHEMBL1258962 | endo-3-(8-(1-(pyridin-4-yl)ethyl)-...) Show SMILES CC(N1[C@H]2CC[C@@H]1C[C@H](C2)Oc1cccc(c1)C(N)=O)c1ccncc1 |r,TLB:1:2:8.7.9:5.4| Show InChI InChI=1S/C21H25N3O2/c1-14(15-7-9-23-10-8-15)24-17-5-6-18(24)13-20(12-17)26-19-4-2-3-16(11-19)21(22)25/h2-4,7-11,14,17-18,20H,5-6,12-13H2,1H3,(H2,22,25)/t14?,17-,18+,20-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50327272 (CHEMBL1258962 | endo-3-(8-(1-(pyridin-4-yl)ethyl)-...) Show SMILES CC(N1[C@H]2CC[C@@H]1C[C@H](C2)Oc1cccc(c1)C(N)=O)c1ccncc1 |r,TLB:1:2:8.7.9:5.4| Show InChI InChI=1S/C21H25N3O2/c1-14(15-7-9-23-10-8-15)24-17-5-6-18(24)13-20(12-17)26-19-4-2-3-16(11-19)21(22)25/h2-4,7-11,14,17-18,20H,5-6,12-13H2,1H3,(H2,22,25)/t14?,17-,18+,20-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human ERG				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50327272 (CHEMBL1258962 | endo-3-(8-(1-(pyridin-4-yl)ethyl)-...) Show SMILES CC(N1[C@H]2CC[C@@H]1C[C@H](C2)Oc1cccc(c1)C(N)=O)c1ccncc1 |r,TLB:1:2:8.7.9:5.4| Show InChI InChI=1S/C21H25N3O2/c1-14(15-7-9-23-10-8-15)24-17-5-6-18(24)13-20(12-17)26-19-4-2-3-16(11-19)21(22)25/h2-4,7-11,14,17-18,20H,5-6,12-13H2,1H3,(H2,22,25)/t14?,17-,18+,20-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair