BDBM50327278 CHEMBL1257459::endo-3-(8-((R)-1-(2-chloropyridin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide

SMILES: C[C@@H](N1[C@H]2CC[C@@H]1C[C@H](C2)Oc1cccc(c1)C(N)=O)c1ccnc(Cl)c1

InChI Key: InChIKey=COVZSEBDZICBKI-UEILYKACSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50327278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50327278 (CHEMBL1257459 | endo-3-(8-((R)-1-(2-chloropyridin-...) Show SMILES C[C@@H](N1[C@H]2CC[C@@H]1C[C@H](C2)Oc1cccc(c1)C(N)=O)c1ccnc(Cl)c1 |r,TLB:1:2:8.7.9:5.4| Show InChI InChI=1S/C21H24ClN3O2/c1-13(14-7-8-24-20(22)10-14)25-16-5-6-17(25)12-19(11-16)27-18-4-2-3-15(9-18)21(23)26/h2-4,7-10,13,16-17,19H,5-6,11-12H2,1H3,(H2,23,26)/t13-,16-,17+,19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	307	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50327278 (CHEMBL1257459 | endo-3-(8-((R)-1-(2-chloropyridin-...) Show SMILES C[C@@H](N1[C@H]2CC[C@@H]1C[C@H](C2)Oc1cccc(c1)C(N)=O)c1ccnc(Cl)c1 |r,TLB:1:2:8.7.9:5.4| Show InChI InChI=1S/C21H24ClN3O2/c1-13(14-7-8-24-20(22)10-14)25-16-5-6-17(25)12-19(11-16)27-18-4-2-3-15(9-18)21(23)26/h2-4,7-10,13,16-17,19H,5-6,11-12H2,1H3,(H2,23,26)/t13-,16-,17+,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human ERG				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50327278 (CHEMBL1257459 | endo-3-(8-((R)-1-(2-chloropyridin-...) Show SMILES C[C@@H](N1[C@H]2CC[C@@H]1C[C@H](C2)Oc1cccc(c1)C(N)=O)c1ccnc(Cl)c1 |r,TLB:1:2:8.7.9:5.4| Show InChI InChI=1S/C21H24ClN3O2/c1-13(14-7-8-24-20(22)10-14)25-16-5-6-17(25)12-19(11-16)27-18-4-2-3-15(9-18)21(23)26/h2-4,7-10,13,16-17,19H,5-6,11-12H2,1H3,(H2,23,26)/t13-,16-,17+,19-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5847-52 (2010) Article DOI: 10.1016/j.bmcl.2010.07.113 BindingDB Entry DOI: 10.7270/Q23F4PV1
					More data for this Ligand-Target Pair