BDBM50327431 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea::CHEMBL1258516

SMILES: O=C(Nc1ccc(cc1)-c1nc(nc(n1)N1CCOCC1)N1C2CCC1COC2)Nc1cccnc1

InChI Key: InChIKey=LRPUTZBETOGWIQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50327431   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50327431 (1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-mo...) Show SMILES O=C(Nc1ccc(cc1)-c1nc(nc(n1)N1CCOCC1)N1C2CCC1COC2)Nc1cccnc1 Show InChI InChI=1S/C25H28N8O3/c34-25(28-19-2-1-9-26-14-19)27-18-5-3-17(4-6-18)22-29-23(32-10-12-35-13-11-32)31-24(30-22)33-20-7-8-21(33)16-36-15-20/h1-6,9,14,20-21H,7-8,10-13,15-16H2,(H2,27,28,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PI3K-alpha				Bioorg Med Chem Lett 20: 5869-73 (2010) Article DOI: 10.1016/j.bmcl.2010.07.104 BindingDB Entry DOI: 10.7270/Q2XP755V
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50327431 (1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-mo...) Show SMILES O=C(Nc1ccc(cc1)-c1nc(nc(n1)N1CCOCC1)N1C2CCC1COC2)Nc1cccnc1 Show InChI InChI=1S/C25H28N8O3/c34-25(28-19-2-1-9-26-14-19)27-18-5-3-17(4-6-18)22-29-23(32-10-12-35-13-11-32)31-24(30-22)33-20-7-8-21(33)16-36-15-20/h1-6,9,14,20-21H,7-8,10-13,15-16H2,(H2,27,28,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of mTOR				Bioorg Med Chem Lett 20: 5869-73 (2010) Article DOI: 10.1016/j.bmcl.2010.07.104 BindingDB Entry DOI: 10.7270/Q2XP755V
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50327431 (1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-mo...) Show SMILES O=C(Nc1ccc(cc1)-c1nc(nc(n1)N1CCOCC1)N1C2CCC1COC2)Nc1cccnc1 Show InChI InChI=1S/C25H28N8O3/c34-25(28-19-2-1-9-26-14-19)27-18-5-3-17(4-6-18)22-29-23(32-10-12-35-13-11-32)31-24(30-22)33-20-7-8-21(33)16-36-15-20/h1-6,9,14,20-21H,7-8,10-13,15-16H2,(H2,27,28,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PI3K-gamma				Bioorg Med Chem Lett 20: 5869-73 (2010) Article DOI: 10.1016/j.bmcl.2010.07.104 BindingDB Entry DOI: 10.7270/Q2XP755V
					More data for this Ligand-Target Pair