Found 7 hits for monomerid = 50327477 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50327477
((R)-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-...)Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3C[C@@H](C)N(CC4CC4)C(=O)c3cc2c1 |r| Show InChI InChI=1S/C24H33N3O2/c1-16(2)25-10-8-20(9-11-25)29-21-6-7-22-19(12-21)13-23-24(28)26(15-18-4-5-18)17(3)14-27(22)23/h6-7,12-13,16-18,20H,4-5,8-11,14-15H2,1-3H3/t17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]-RAMH from human histamine H3 receptor |
Bioorg Med Chem Lett 20: 5713-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50327477
((R)-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-...)Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3C[C@@H](C)N(CC4CC4)C(=O)c3cc2c1 |r| Show InChI InChI=1S/C24H33N3O2/c1-16(2)25-10-8-20(9-11-25)29-21-6-7-22-19(12-21)13-23-24(28)26(15-18-4-5-18)17(3)14-27(22)23/h6-7,12-13,16-18,20H,4-5,8-11,14-15H2,1-3H3/t17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Binding affinity to rat histamine H3 receptor |
Bioorg Med Chem Lett 20: 5713-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50327477
((R)-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-...)Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3C[C@@H](C)N(CC4CC4)C(=O)c3cc2c1 |r| Show InChI InChI=1S/C24H33N3O2/c1-16(2)25-10-8-20(9-11-25)29-21-6-7-22-19(12-21)13-23-24(28)26(15-18-4-5-18)17(3)14-27(22)23/h6-7,12-13,16-18,20H,4-5,8-11,14-15H2,1-3H3/t17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
F Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Inverse agonist activity at human recombinant histamine H3 receptor assessed as effect on [35S]GTPgammaS binding |
Bioorg Med Chem Lett 20: 5713-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50327477
((R)-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-...)Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3C[C@@H](C)N(CC4CC4)C(=O)c3cc2c1 |r| Show InChI InChI=1S/C24H33N3O2/c1-16(2)25-10-8-20(9-11-25)29-21-6-7-22-19(12-21)13-23-24(28)26(15-18-4-5-18)17(3)14-27(22)23/h6-7,12-13,16-18,20H,4-5,8-11,14-15H2,1-3H3/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
F Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 |
Bioorg Med Chem Lett 20: 5713-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50327477
((R)-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-...)Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3C[C@@H](C)N(CC4CC4)C(=O)c3cc2c1 |r| Show InChI InChI=1S/C24H33N3O2/c1-16(2)25-10-8-20(9-11-25)29-21-6-7-22-19(12-21)13-23-24(28)26(15-18-4-5-18)17(3)14-27(22)23/h6-7,12-13,16-18,20H,4-5,8-11,14-15H2,1-3H3/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
F Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Inhibition of CYP2C9 |
Bioorg Med Chem Lett 20: 5713-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50327477
((R)-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-...)Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3C[C@@H](C)N(CC4CC4)C(=O)c3cc2c1 |r| Show InChI InChI=1S/C24H33N3O2/c1-16(2)25-10-8-20(9-11-25)29-21-6-7-22-19(12-21)13-23-24(28)26(15-18-4-5-18)17(3)14-27(22)23/h6-7,12-13,16-18,20H,4-5,8-11,14-15H2,1-3H3/t17-/m1/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
F Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 |
Bioorg Med Chem Lett 20: 5713-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50327477
((R)-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-...)Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3C[C@@H](C)N(CC4CC4)C(=O)c3cc2c1 |r| Show InChI InChI=1S/C24H33N3O2/c1-16(2)25-10-8-20(9-11-25)29-21-6-7-22-19(12-21)13-23-24(28)26(15-18-4-5-18)17(3)14-27(22)23/h6-7,12-13,16-18,20H,4-5,8-11,14-15H2,1-3H3/t17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
F Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Inverse agonist activity at rat histamine H3 receptor |
Bioorg Med Chem Lett 20: 5713-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N |
More data for this Ligand-Target Pair | |