BDBM50327495 2-isopropyl-8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one::CHEMBL1258874

SMILES: CC(C)N1CCC(CC1)Oc1ccc2n3CCN(C(C)C)C(=O)c3cc2c1

InChI Key: InChIKey=SMRRGJLLFFKDID-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50327495   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327495 (2-isopropyl-8-(1-isopropylpiperidin-4-yloxy)-3,4-d...) Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3CCN(C(C)C)C(=O)c3cc2c1 Show InChI InChI=1S/C22H31N3O2/c1-15(2)23-9-7-18(8-10-23)27-19-5-6-20-17(13-19)14-21-22(26)24(16(3)4)11-12-25(20)21/h5-6,13-16,18H,7-12H2,1-4H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-RAMH from human histamine H3 receptor				Bioorg Med Chem Lett 20: 5713-7 (2010) Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327495 (2-isopropyl-8-(1-isopropylpiperidin-4-yloxy)-3,4-d...) Show SMILES CC(C)N1CCC(CC1)Oc1ccc2n3CCN(C(C)C)C(=O)c3cc2c1 Show InChI InChI=1S/C22H31N3O2/c1-15(2)23-9-7-18(8-10-23)27-19-5-6-20-17(13-19)14-21-22(26)24(16(3)4)11-12-25(20)21/h5-6,13-16,18H,7-12H2,1-4H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
F Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Inverse agonist activity at human recombinant histamine H3 receptor assessed as effect on [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5713-7 (2010) Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N
					More data for this Ligand-Target Pair