BDBM50327500 2-(5-(1H-indazol-5-yl)pyridin-3-yl)-1-fluoroethane-1,1-diyldiphosphonic acid::CHEMBL1258421

SMILES: OP(O)(=O)C(F)(Cc1cncc(c1)-c1ccc2[nH]ncc2c1)P(O)(O)=O

InChI Key: InChIKey=MLYBZHHGRJJXOT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50327500   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Farnesyl diphosphate synthase (Homo sapiens (Human))	BDBM50327500 (2-(5-(1H-indazol-5-yl)pyridin-3-yl)-1-fluoroethane...) Show SMILES OP(O)(=O)C(F)(Cc1cncc(c1)-c1ccc2[nH]ncc2c1)P(O)(O)=O Show InChI InChI=1S/C14H14FN3O6P2/c15-14(25(19,20)21,26(22,23)24)5-9-3-11(7-16-6-9)10-1-2-13-12(4-10)8-17-18-13/h1-4,6-8H,5H2,(H,17,18)(H2,19,20,21)(H2,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...				J Med Chem 55: 3201-15 (2012) Article DOI: 10.1021/jm201657x BindingDB Entry DOI: 10.7270/Q29024V1
					More data for this Ligand-Target Pair
Farnesyl diphosphate synthase (Homo sapiens (Human))	BDBM50327500 (2-(5-(1H-indazol-5-yl)pyridin-3-yl)-1-fluoroethane...) Show SMILES OP(O)(=O)C(F)(Cc1cncc(c1)-c1ccc2[nH]ncc2c1)P(O)(O)=O Show InChI InChI=1S/C14H14FN3O6P2/c15-14(25(19,20)21,26(22,23)24)5-9-3-11(7-16-6-9)10-1-2-13-12(4-10)8-17-18-13/h1-4,6-8H,5H2,(H,17,18)(H2,19,20,21)(H2,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli				Bioorg Med Chem Lett 20: 5781-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.133 BindingDB Entry DOI: 10.7270/Q21G0MGG
					More data for this Ligand-Target Pair