BDBM50328139 CHEMBL1241934::N4-(2-morpholinoethyl)-N6-(4-(trifluoromethoxy)phenyl)pyrimidine-4,6-diamine

SMILES: FC(F)(F)Oc1ccc(Nc2cc(NCCN3CCOCC3)ncn2)cc1

InChI Key: InChIKey=DGFBDHCOFRXYQX-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328139   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcr-Abl (Homo sapiens (Human))	BDBM50328139 (CHEMBL1241934 | N4-(2-morpholinoethyl)-N6-(4-(trif...) Show SMILES FC(F)(F)Oc1ccc(Nc2cc(NCCN3CCOCC3)ncn2)cc1 Show InChI InChI=1S/C17H20F3N5O2/c18-17(19,20)27-14-3-1-13(2-4-14)24-16-11-15(22-12-23-16)21-5-6-25-7-9-26-10-8-25/h1-4,11-12H,5-10H2,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	720	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of Bcr-Abl in mouse BA/F3 cells				J Med Chem 53: 6934-46 (2010) Article DOI: 10.1021/jm100555f BindingDB Entry DOI: 10.7270/Q2DJ5FTW
					More data for this Ligand-Target Pair