BDBM50328155 CHEMBL1257539::morpholino(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)phenyl)methanone

SMILES: FC(F)(F)Oc1ccc(Nc2cc(ncn2)-c2cccc(c2)C(=O)N2CCOCC2)cc1

InChI Key: InChIKey=KYRATOJAAZCVAH-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328155   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcr-Abl (Homo sapiens (Human))	BDBM50328155 (CHEMBL1257539 | morpholino(3-(6-(4-(trifluorometho...) Show SMILES FC(F)(F)Oc1ccc(Nc2cc(ncn2)-c2cccc(c2)C(=O)N2CCOCC2)cc1 Show InChI InChI=1S/C22H19F3N4O3/c23-22(24,25)32-18-6-4-17(5-7-18)28-20-13-19(26-14-27-20)15-2-1-3-16(12-15)21(30)29-8-10-31-11-9-29/h1-7,12-14H,8-11H2,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	240	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of Bcr-Abl in mouse BA/F3 cells				J Med Chem 53: 6934-46 (2010) Article DOI: 10.1021/jm100555f BindingDB Entry DOI: 10.7270/Q2DJ5FTW
					More data for this Ligand-Target Pair