new BindingDB logo
myBDB logout

BDBM50328275 7-chloro-5-phenyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine::CHEMBL1257672

SMILES: Clc1ccc2Nc3[nH]ncc3N=C(c3ccccc3)c2c1

InChI Key: InChIKey=CEAXVTLPJBOZPX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328275   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK2/Cyclin E/G1/S-specific cyclin E2


(Homo sapiens (Human))
BDBM50328275
PNG
(7-chloro-5-phenyl-2,10-dihydrobenzo[e]pyrazolo[4,3...)
Show SMILES Clc1ccc2Nc3[nH]ncc3N=C(c3ccccc3)c2c1 |t:12|
Show InChI InChI=1S/C16H11ClN4/c17-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)19-14-9-18-21-16(14)20-13/h1-9H,(H2,18,20,21)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 490n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2-cyclin E


Bioorg Med Chem Lett 20: 5984-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.079
BindingDB Entry DOI: 10.7270/Q21C1X42
More data for this
Ligand-Target Pair