BDBM50328408 (Z)-3-((4-(3-(diethylamino)propoxy)-3-methylazulen-1-yl)methylene)-5-fluoroindolin-2-one::CHEMBL1258265

SMILES: CCN(CC)CCCOc1ccccc2c(\C=C3/C(=O)Nc4ccc(F)cc34)cc(C)c12

InChI Key: InChIKey=FDSSIMWUNGQCAX-KQWNVCNZSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328408   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50328408 ((Z)-3-((4-(3-(diethylamino)propoxy)-3-methylazulen...) Show SMILES CCN(CC)CCCOc1ccccc2c(\C=C3/C(=O)Nc4ccc(F)cc34)cc(C)c12 Show InChI InChI=1S/C27H29FN2O2/c1-4-30(5-2)13-8-14-32-25-10-7-6-9-21-19(15-18(3)26(21)25)16-23-22-17-20(28)11-12-24(22)29-27(23)31/h6-7,9-12,15-17H,4-5,8,13-14H2,1-3H3,(H,29,31)/b23-16-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Industrial Technology Research Institute Curated by ChEMBL					Assay Description Inhibition of FLT3 by time resolved fluorescence method				Bioorg Med Chem Lett 20: 6129-32 (2010) Article DOI: 10.1016/j.bmcl.2010.08.025 BindingDB Entry DOI: 10.7270/Q2N29X51
					More data for this Ligand-Target Pair