BDBM50328422 CHEMBL1257331::N-(4-methoxyphenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine

SMILES: COc1ccc(Nc2nc(cn3ccnc23)-c2cccnc2)cc1

InChI Key: InChIKey=LNJAISXLOWYEFZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328422   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50328422 (CHEMBL1257331 | N-(4-methoxyphenyl)-6-(pyridin-3-y...) Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccnc2)cc1 Show InChI InChI=1S/C18H15N5O/c1-24-15-6-4-14(5-7-15)21-17-18-20-9-10-23(18)12-16(22-17)13-3-2-8-19-11-13/h2-12H,1H3,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of human aurora A				Bioorg Med Chem Lett 20: 5988-93 (2010) Article DOI: 10.1016/j.bmcl.2010.08.091 BindingDB Entry DOI: 10.7270/Q2H995D7
					More data for this Ligand-Target Pair