BDBM50328425 CHEMBL1257445::N-(4-(6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-ylamino)phenyl)benzamide

SMILES: O=C(Nc1ccc(Nc2nc(cn3ccnc23)-c2cccnc2)cc1)c1ccccc1

InChI Key: InChIKey=TUVOCSLEDZZBSS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328425   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50328425 (CHEMBL1257445 | N-(4-(6-(pyridin-3-yl)imidazo[1,2-...) Show SMILES O=C(Nc1ccc(Nc2nc(cn3ccnc23)-c2cccnc2)cc1)c1ccccc1 Show InChI InChI=1S/C24H18N6O/c31-24(17-5-2-1-3-6-17)28-20-10-8-19(9-11-20)27-22-23-26-13-14-30(23)16-21(29-22)18-7-4-12-25-15-18/h1-16H,(H,27,29)(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of human aurora A				Bioorg Med Chem Lett 20: 5988-93 (2010) Article DOI: 10.1016/j.bmcl.2010.08.091 BindingDB Entry DOI: 10.7270/Q2H995D7
					More data for this Ligand-Target Pair