BDBM50328427 6-(3-aminophenyl)-N-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-amine::CHEMBL1258033

SMILES: COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(N)c2)cc1

InChI Key: InChIKey=CZCFVUASEDHTAW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328427   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50328427 (6-(3-aminophenyl)-N-(4-methoxyphenyl)imidazo[1,2-a...) Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(N)c2)cc1 Show InChI InChI=1S/C19H17N5O/c1-25-16-7-5-15(6-8-16)22-18-19-21-9-10-24(19)12-17(23-18)13-3-2-4-14(20)11-13/h2-12H,20H2,1H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of human aurora A				Bioorg Med Chem Lett 20: 5988-93 (2010) Article DOI: 10.1016/j.bmcl.2010.08.091 BindingDB Entry DOI: 10.7270/Q2H995D7
					More data for this Ligand-Target Pair