BDBM50328430 1-(4-methoxyphenyl)-3-(3-(8-(4-methoxyphenylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)urea::CHEMBL1258267

SMILES: COc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(Nc3ccc(OC)cc3)n2)cc1

InChI Key: InChIKey=OYJUNIKRBCEEIS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328430   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50328430 (1-(4-methoxyphenyl)-3-(3-(8-(4-methoxyphenylamino)...) Show SMILES COc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(Nc3ccc(OC)cc3)n2)cc1 Show InChI InChI=1S/C27H24N6O3/c1-35-22-10-6-19(7-11-22)29-25-26-28-14-15-33(26)17-24(32-25)18-4-3-5-21(16-18)31-27(34)30-20-8-12-23(36-2)13-9-20/h3-17H,1-2H3,(H,29,32)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of human aurora A				Bioorg Med Chem Lett 20: 5988-93 (2010) Article DOI: 10.1016/j.bmcl.2010.08.091 BindingDB Entry DOI: 10.7270/Q2H995D7
					More data for this Ligand-Target Pair