BDBM50328602 1-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one::CHEMBL1259136

SMILES: CN1CCN(Cc2ccc(cc2)-n2c3c(ccc2=O)cnc2ccc(cc32)-c2cnc3ccccc3c2)CC1

InChI Key: InChIKey=MLRYKMPLYNACRR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328602   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (mTOR) (Mus musculus (Mouse))	BDBM50328602 (1-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-9-(qu...) Show SMILES CN1CCN(Cc2ccc(cc2)-n2c3c(ccc2=O)cnc2ccc(cc32)-c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C33H29N5O/c1-36-14-16-37(17-15-36)22-23-6-10-28(11-7-23)38-32(39)13-9-26-20-35-31-12-8-24(19-29(31)33(26)38)27-18-25-4-2-3-5-30(25)34-21-27/h2-13,18-21H,14-17,22H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 53: 7146-55 (2010) Article DOI: 10.1021/jm101144f BindingDB Entry DOI: 10.7270/Q2M32W0R
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50328602 (1-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-9-(qu...) Show SMILES CN1CCN(Cc2ccc(cc2)-n2c3c(ccc2=O)cnc2ccc(cc32)-c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C33H29N5O/c1-36-14-16-37(17-15-36)22-23-6-10-28(11-7-23)38-32(39)13-9-26-20-35-31-12-8-24(19-29(31)33(26)38)27-18-25-4-2-3-5-30(25)34-21-27/h2-13,18-21H,14-17,22H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of human mTOR complex 1 after 30 mins by FRET assay				J Med Chem 53: 7146-55 (2010) Article DOI: 10.1021/jm101144f BindingDB Entry DOI: 10.7270/Q2M32W0R
					More data for this Ligand-Target Pair