BDBM50329066 CHEMBL1271287::N2-(3,5-dimorpholinophenyl)-N4-(1H-indazol-7-yl)pyrimidine-2,4-diamine

SMILES: C1CN(CCO1)c1cc(Nc2nccc(Nc3cccc4cn[nH]c34)n2)cc(c1)N1CCOCC1

InChI Key: InChIKey=PDKQWKZLHGNIBX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329066   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50329066 (CHEMBL1271287 | N2-(3,5-dimorpholinophenyl)-N4-(1H...) Show SMILES C1CN(CCO1)c1cc(Nc2nccc(Nc3cccc4cn[nH]c34)n2)cc(c1)N1CCOCC1 Show InChI InChI=1S/C25H28N8O2/c1-2-18-17-27-31-24(18)22(3-1)29-23-4-5-26-25(30-23)28-19-14-20(32-6-10-34-11-7-32)16-21(15-19)33-8-12-35-13-9-33/h1-5,14-17H,6-13H2,(H,27,31)(H2,26,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation expressed in CHOK1 cells				Bioorg Med Chem Lett 20: 6242-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.100 BindingDB Entry DOI: 10.7270/Q2QR4XCB
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50329066 (CHEMBL1271287 | N2-(3,5-dimorpholinophenyl)-N4-(1H...) Show SMILES C1CN(CCO1)c1cc(Nc2nccc(Nc3cccc4cn[nH]c34)n2)cc(c1)N1CCOCC1 Show InChI InChI=1S/C25H28N8O2/c1-2-18-17-27-31-24(18)22(3-1)29-23-4-5-26-25(30-23)28-19-14-20(32-6-10-34-11-7-32)16-21(15-19)33-8-12-35-13-9-33/h1-5,14-17H,6-13H2,(H,27,31)(H2,26,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EphB4 by acoustic dispensing assay				Bioorg Med Chem Lett 20: 6242-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.100 BindingDB Entry DOI: 10.7270/Q2QR4XCB
					More data for this Ligand-Target Pair