BDBM50329073 3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)-N,N-dimethylbenzamide::CHEMBL1269965

SMILES: CN(C)C(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1

InChI Key: InChIKey=QGOCMYWLKNVDRG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329073   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50329073 (3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)-N,...) Show SMILES CN(C)C(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1 Show InChI InChI=1S/C20H19N7O/c1-27(2)19(28)13-5-3-6-14(11-13)23-20-21-10-9-18(25-20)24-16-7-4-8-17-15(16)12-22-26-17/h3-12H,1-2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation expressed in CHOK1 cells				Bioorg Med Chem Lett 20: 6242-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.100 BindingDB Entry DOI: 10.7270/Q2QR4XCB
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50329073 (3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)-N,...) Show SMILES CN(C)C(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1 Show InChI InChI=1S/C20H19N7O/c1-27(2)19(28)13-5-3-6-14(11-13)23-20-21-10-9-18(25-20)24-16-7-4-8-17-15(16)12-22-26-17/h3-12H,1-2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	246	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EphB4 by acoustic dispensing assay				Bioorg Med Chem Lett 20: 6242-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.100 BindingDB Entry DOI: 10.7270/Q2QR4XCB
					More data for this Ligand-Target Pair