BDBM50329212 CHEMBL1271417::N-benzyl-5-(4-chlorophenyl)nicotinamide
SMILES: Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1
InChI Key: InChIKey=FWHXSLFSGPLDBM-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-gated sodium channel subunit alpha Nav1.8 (Rattus norvegicus (Rat)) | BDBM50329212 (CHEMBL1271417 | N-benzyl-5-(4-chlorophenyl)nicotin...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology | Bioorg Med Chem Lett 20: 6812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.121 BindingDB Entry DOI: 10.7270/Q2F76CS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type X alpha subunit (Mus musculus) | BDBM50329212 (CHEMBL1271417 | N-benzyl-5-(4-chlorophenyl)nicotin...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of mouse NaV1.8 by electrophysiology | Bioorg Med Chem Lett 20: 6812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.121 BindingDB Entry DOI: 10.7270/Q2F76CS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human)) | BDBM50329212 (CHEMBL1271417 | N-benzyl-5-(4-chlorophenyl)nicotin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of human NaV1.8 by electrophysiology | Bioorg Med Chem Lett 20: 6812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.121 BindingDB Entry DOI: 10.7270/Q2F76CS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human)) | BDBM50329212 (CHEMBL1271417 | N-benzyl-5-(4-chlorophenyl)nicotin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of human NaV1.2 by electrophysiology | Bioorg Med Chem Lett 20: 6812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.121 BindingDB Entry DOI: 10.7270/Q2F76CS6 | |||||||||||
More data for this Ligand-Target Pair |