BDBM50329214 CHEMBL1271415::N-(3,5-dimethylphenyl)-5-(4-fluorophenyl)nicotinamide

SMILES: Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(F)cc2)c1

InChI Key: InChIKey=XJXXETPSJSPVGG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50329214   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated sodium channel subunit alpha Nav1.8 (Rattus norvegicus (Rat))	BDBM50329214 (CHEMBL1271415 | N-(3,5-dimethylphenyl)-5-(4-fluoro...) Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(F)cc2)c1 Show InChI InChI=1S/C20H17FN2O/c1-13-7-14(2)9-19(8-13)23-20(24)17-10-16(11-22-12-17)15-3-5-18(21)6-4-15/h3-12H,1-2H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology				Bioorg Med Chem Lett 20: 6812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.121 BindingDB Entry DOI: 10.7270/Q2F76CS6
					More data for this Ligand-Target Pair
Sodium channel protein type X alpha subunit (Mus musculus)	BDBM50329214 (CHEMBL1271415 | N-(3,5-dimethylphenyl)-5-(4-fluoro...) Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(F)cc2)c1 Show InChI InChI=1S/C20H17FN2O/c1-13-7-14(2)9-19(8-13)23-20(24)17-10-16(11-22-12-17)15-3-5-18(21)6-4-15/h3-12H,1-2H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse NaV1.8 by electrophysiology				Bioorg Med Chem Lett 20: 6812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.121 BindingDB Entry DOI: 10.7270/Q2F76CS6
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM50329214 (CHEMBL1271415 | N-(3,5-dimethylphenyl)-5-(4-fluoro...) Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(F)cc2)c1 Show InChI InChI=1S/C20H17FN2O/c1-13-7-14(2)9-19(8-13)23-20(24)17-10-16(11-22-12-17)15-3-5-18(21)6-4-15/h3-12H,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human NaV1.8 by electrophysiology				Bioorg Med Chem Lett 20: 6812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.121 BindingDB Entry DOI: 10.7270/Q2F76CS6
					More data for this Ligand-Target Pair