BDBM50329797 (Z)-N-ethyl-3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide::CHEMBL1271853

SMILES: CCNC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1

InChI Key: InChIKey=BIRMNZNMTFDQFC-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50329797   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50329797 ((Z)-N-ethyl-3-((4-(N-methyl-2-(4-methylpiperazin-1...) Show SMILES CCNC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:11.11| Show InChI InChI=1S/C32H36N6O3/c1-4-33-31(40)23-10-15-26-27(20-23)35-32(41)29(26)30(22-8-6-5-7-9-22)34-24-11-13-25(14-12-24)37(3)28(39)21-38-18-16-36(2)17-19-38/h5-15,20,29H,4,16-19,21H2,1-3H3,(H,33,40)(H,35,41)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH& Co KG Curated by ChEMBL					Assay Description Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISA				J Med Chem 53: 7287-95 (2010) Article DOI: 10.1021/jm100812a BindingDB Entry DOI: 10.7270/Q2F47PCW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50329797 ((Z)-N-ethyl-3-((4-(N-methyl-2-(4-methylpiperazin-1...) Show SMILES CCNC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:11.11| Show InChI InChI=1S/C32H36N6O3/c1-4-33-31(40)23-10-15-26-27(20-23)35-32(41)29(26)30(22-8-6-5-7-9-22)34-24-11-13-25(14-12-24)37(3)28(39)21-38-18-16-36(2)17-19-38/h5-15,20,29H,4,16-19,21H2,1-3H3,(H,33,40)(H,35,41)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH& Co KG Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha				J Med Chem 53: 7287-95 (2010) Article DOI: 10.1021/jm100812a BindingDB Entry DOI: 10.7270/Q2F47PCW
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50329797 ((Z)-N-ethyl-3-((4-(N-methyl-2-(4-methylpiperazin-1...) Show SMILES CCNC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:11.11| Show InChI InChI=1S/C32H36N6O3/c1-4-33-31(40)23-10-15-26-27(20-23)35-32(41)29(26)30(22-8-6-5-7-9-22)34-24-11-13-25(14-12-24)37(3)28(39)21-38-18-16-36(2)17-19-38/h5-15,20,29H,4,16-19,21H2,1-3H3,(H,33,40)(H,35,41)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH& Co KG Curated by ChEMBL					Assay Description Inhibition of TGFbeta receptor				J Med Chem 53: 7287-95 (2010) Article DOI: 10.1021/jm100812a BindingDB Entry DOI: 10.7270/Q2F47PCW
					More data for this Ligand-Target Pair