BDBM50329887 CHEMBL1271978::N-(6-(4-(allyloxy)-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-yl)-2-chloroacetamide

SMILES: FC(F)(F)c1cc(OCC=C)nc(n1)-c1ccc(NC(=O)CCl)cn1

InChI Key: InChIKey=VXJHIIBUFJFRMV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329887   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50329887 (CHEMBL1271978 | N-(6-(4-(allyloxy)-6-(trifluoromet...) Show SMILES FC(F)(F)c1cc(OCC=C)nc(n1)-c1ccc(NC(=O)CCl)cn1 Show InChI InChI=1S/C15H12ClF3N4O2/c1-2-5-25-13-6-11(15(17,18)19)22-14(23-13)10-4-3-9(8-20-10)21-12(24)7-16/h2-4,6,8H,1,5,7H2,(H,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Life Sciences Curated by ChEMBL					Assay Description Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assay				Bioorg Med Chem Lett 20: 6426-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.083 BindingDB Entry DOI: 10.7270/Q2HX1CXM
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50329887 (CHEMBL1271978 | N-(6-(4-(allyloxy)-6-(trifluoromet...) Show SMILES FC(F)(F)c1cc(OCC=C)nc(n1)-c1ccc(NC(=O)CCl)cn1 Show InChI InChI=1S/C15H12ClF3N4O2/c1-2-5-25-13-6-11(15(17,18)19)22-14(23-13)10-4-3-9(8-20-10)21-12(24)7-16/h2-4,6,8H,1,5,7H2,(H,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Life Sciences Curated by ChEMBL					Assay Description Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay				Bioorg Med Chem Lett 20: 6426-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.083 BindingDB Entry DOI: 10.7270/Q2HX1CXM
					More data for this Ligand-Target Pair