BDBM50330105 CHEMBL1271659::N-(6-(3-(pyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)pyridazin-3-yl)benzamide
SMILES: FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)nn1)-c1cccnc1
InChI Key: InChIKey=YPNVSGHDSJGBEO-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM50330105 (CHEMBL1271659 | N-(6-(3-(pyridin-3-yl)-5-(trifluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay | Bioorg Med Chem Lett 20: 6379-83 (2010) Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM50330105 (CHEMBL1271659 | N-(6-(3-(pyridin-3-yl)-5-(trifluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay | Bioorg Med Chem Lett 20: 6379-83 (2010) Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 | |||||||||||
More data for this Ligand-Target Pair |