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BDBM50330690 5-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-2-phenyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione::CHEMBL1277213

SMILES: Cc1n(Cc2ccc3OCOc3c2)c(=O)cc2[nH]n(-c3ccccc3)c(=O)c12

InChI Key: InChIKey=ANUFFQUQIIVNIW-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50330690   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330690
PNG
(5-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-2-phen...)
Show SMILES Cc1n(Cc2ccc3OCOc3c2)c(=O)cc2[nH]n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C21H17N3O4/c1-13-20-16(22-24(21(20)26)15-5-3-2-4-6-15)10-19(25)23(13)11-14-7-8-17-18(9-14)28-12-27-17/h2-10,22H,11-12H2,1H3
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Similars

Article
PubMed
5.44E+3n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair