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BDBM50330728 2-(2-(4-chlorophenoxy)ethyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione::CHEMBL1277214

SMILES: Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(CCOc3ccc(Cl)cc3)c(=O)c12

InChI Key: InChIKey=DKGSXHQOYLMYAX-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50330728   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50330728
PNG
(2-(2-(4-chlorophenoxy)ethyl)-4-methyl-5-(pyridin-2...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(CCOc3ccc(Cl)cc3)c(=O)c12
Show InChI InChI=1S/C21H19ClN4O3/c1-14-20-18(12-19(27)25(14)13-16-4-2-3-9-23-16)24-26(21(20)28)10-11-29-17-7-5-15(22)6-8-17/h2-9,12,24H,10-11,13H2,1H3
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Article
PubMed
 326n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH

J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair