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BDBM50330788 CHEMBL1277500::N1-Methyl-N2-phenyl-N2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-ethane-1,2-diamine

SMILES: CNCCN(c1ccccc1)c1ccc(OCCN2CCCC2)cc1

InChI Key: InChIKey=LBBBRPSDINTRFT-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330788   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50330788
PNG
(CHEMBL1277500 | N1-Methyl-N2-phenyl-N2-(4-(2-(pyrr...)
Show SMILES CNCCN(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C21H29N3O/c1-22-13-16-24(19-7-3-2-4-8-19)20-9-11-21(12-10-20)25-18-17-23-14-5-6-15-23/h2-4,7-12,22H,5-6,13-18H2,1H3
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1.60n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-R-methylhistamine from human H3 receptor isolated from C6 cells


J Med Chem 53: 7869-73 (2010)


Article DOI: 10.1021/jm100666w
BindingDB Entry DOI: 10.7270/Q2P84C4F
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50330788
PNG
(CHEMBL1277500 | N1-Methyl-N2-phenyl-N2-(4-(2-(pyrr...)
Show SMILES CNCCN(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C21H29N3O/c1-22-13-16-24(19-7-3-2-4-8-19)20-9-11-21(12-10-20)25-18-17-23-14-5-6-15-23/h2-4,7-12,22H,5-6,13-18H2,1H3
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PC sid
UniChem
Article
PubMed
5.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-R-methylhistamine from rat H3 receptor


J Med Chem 53: 7869-73 (2010)


Article DOI: 10.1021/jm100666w
BindingDB Entry DOI: 10.7270/Q2P84C4F
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50330788
PNG
(CHEMBL1277500 | N1-Methyl-N2-phenyl-N2-(4-(2-(pyrr...)
Show SMILES CNCCN(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C21H29N3O/c1-22-13-16-24(19-7-3-2-4-8-19)20-9-11-21(12-10-20)25-18-17-23-14-5-6-15-23/h2-4,7-12,22H,5-6,13-18H2,1H3
PDB

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antibodypedia
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PC sid
UniChem
Article
PubMed
>70n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of SERT


J Med Chem 53: 7869-73 (2010)


Article DOI: 10.1021/jm100666w
BindingDB Entry DOI: 10.7270/Q2P84C4F
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus (rat))
BDBM50330788
PNG
(CHEMBL1277500 | N1-Methyl-N2-phenyl-N2-(4-(2-(pyrr...)
Show SMILES CNCCN(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C21H29N3O/c1-22-13-16-24(19-7-3-2-4-8-19)20-9-11-21(12-10-20)25-18-17-23-14-5-6-15-23/h2-4,7-12,22H,5-6,13-18H2,1H3
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UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
89n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from rat NET in rat cerebral cortex


J Med Chem 53: 7869-73 (2010)


Article DOI: 10.1021/jm100666w
BindingDB Entry DOI: 10.7270/Q2P84C4F
More data for this
Ligand-Target Pair