BDBM50330940 CHEMBL1276881::N-((2-Chloropyridin-3-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)pyrazine-2-carboxamide

SMILES: FC(F)(F)Oc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1Cl

InChI Key: InChIKey=RJLVNBBRFOUABG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330940   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type X alpha subunit (Mus musculus)	BDBM50330940 (CHEMBL1276881 | N-((2-Chloropyridin-3-yl)methyl)-6...) Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1Cl Show InChI InChI=1S/C18H12ClF3N4O2/c19-16-12(2-1-7-24-16)8-25-17(27)15-10-23-9-14(26-15)11-3-5-13(6-4-11)28-18(20,21)22/h1-7,9-10H,8H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assay				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM50330940 (CHEMBL1276881 | N-((2-Chloropyridin-3-yl)methyl)-6...) Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1Cl Show InChI InChI=1S/C18H12ClF3N4O2/c19-16-12(2-1-7-24-16)8-25-17(27)15-10-23-9-14(26-15)11-3-5-13(6-4-11)28-18(20,21)22/h1-7,9-10H,8H2,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assay				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8 (Rattus norvegicus (Rat))	BDBM50330940 (CHEMBL1276881 | N-((2-Chloropyridin-3-yl)methyl)-6...) Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1Cl Show InChI InChI=1S/C18H12ClF3N4O2/c19-16-12(2-1-7-24-16)8-25-17(27)15-10-23-9-14(26-15)11-3-5-13(6-4-11)28-18(20,21)22/h1-7,9-10H,8H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM50330940 (CHEMBL1276881 | N-((2-Chloropyridin-3-yl)methyl)-6...) Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1Cl Show InChI InChI=1S/C18H12ClF3N4O2/c19-16-12(2-1-7-24-16)8-25-17(27)15-10-23-9-14(26-15)11-3-5-13(6-4-11)28-18(20,21)22/h1-7,9-10H,8H2,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant NaV1.2 by electrophysiology				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair