BDBM50330946 CHEMBL1277700::N-((2-Morpholin-4-yl-pyridin-3-yl)methyl)-6-(4-chlorophenyl)-pyrazine-2-carboxamide

SMILES: Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCOCC1

InChI Key: InChIKey=NEGLDDATOGSCRT-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50330946   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type X alpha subunit (Mus musculus)	BDBM50330946 (CHEMBL1277700 | N-((2-Morpholin-4-yl-pyridin-3-yl)...) Show SMILES Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCOCC1 Show InChI InChI=1S/C21H20ClN5O2/c22-17-5-3-15(4-6-17)18-13-23-14-19(26-18)21(28)25-12-16-2-1-7-24-20(16)27-8-10-29-11-9-27/h1-7,13-14H,8-12H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assay				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM50330946 (CHEMBL1277700 | N-((2-Morpholin-4-yl-pyridin-3-yl)...) Show SMILES Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCOCC1 Show InChI InChI=1S/C21H20ClN5O2/c22-17-5-3-15(4-6-17)18-13-23-14-19(26-18)21(28)25-12-16-2-1-7-24-20(16)27-8-10-29-11-9-27/h1-7,13-14H,8-12H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assay				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8 (Rattus norvegicus (Rat))	BDBM50330946 (CHEMBL1277700 | N-((2-Morpholin-4-yl-pyridin-3-yl)...) Show SMILES Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCOCC1 Show InChI InChI=1S/C21H20ClN5O2/c22-17-5-3-15(4-6-17)18-13-23-14-19(26-18)21(28)25-12-16-2-1-7-24-20(16)27-8-10-29-11-9-27/h1-7,13-14H,8-12H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair