BDBM50331026 (Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-dimethylamino-ethyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one::CHEMBL1278234

SMILES: CN(C)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O

InChI Key: InChIKey=GSURAMUGDNSWKE-PTNGSMBKSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331026   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331026 ((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...) Show SMILES CN(C)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O Show InChI InChI=1S/C21H23FN4O2/c1-12-18(11-15-14-10-13(22)4-5-16(14)24-20(15)27)23-17-6-7-26(9-8-25(2)3)21(28)19(12)17/h4-5,10-11,23H,6-9H2,1-3H3,(H,24,27)/b15-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331026 ((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...) Show SMILES CN(C)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O Show InChI InChI=1S/C21H23FN4O2/c1-12-18(11-15-14-10-13(22)4-5-16(14)24-20(15)27)23-17-6-7-26(9-8-25(2)3)21(28)19(12)17/h4-5,10-11,23H,6-9H2,1-3H3,(H,24,27)/b15-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of VEGFR2-induced cell proliferation in HUVEC after 72 hrs by sulforhodamine B method				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50331026 ((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...) Show SMILES CN(C)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O Show InChI InChI=1S/C21H23FN4O2/c1-12-18(11-15-14-10-13(22)4-5-16(14)24-20(15)27)23-17-6-7-26(9-8-25(2)3)21(28)19(12)17/h4-5,10-11,23H,6-9H2,1-3H3,(H,24,27)/b15-11-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of c-Kit after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50331026 ((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...) Show SMILES CN(C)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O Show InChI InChI=1S/C21H23FN4O2/c1-12-18(11-15-14-10-13(22)4-5-16(14)24-20(15)27)23-17-6-7-26(9-8-25(2)3)21(28)19(12)17/h4-5,10-11,23H,6-9H2,1-3H3,(H,24,27)/b15-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human PDGFRbeta after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair