BindingDB PrimarySearch

BDBM50331095 CHEMBL1289494::Tivozanib::US10464902, Tivozanib

SMILES: COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC

InChI Key: InChIKey=SPMVMDHWKHCIDT-UHFFFAOYSA-N

Data: 1 KI 19 IC50 1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50331095
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	US Patent	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ontogenesis, LLC US Patent					Assay Description Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...				US Patent US10464902 (2019) BindingDB Entry DOI: 10.7270/Q2R213S2
Ontogenesis, LLC US Patent					More data for this Ligand-Target Pair
Fibroblast growth factor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
Nanjing University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	42.4	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
Nanjing University					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (EPHA2) (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	259	n/a	n/a	n/a	n/a	n/a
Technical University of Munich					Assay Description Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...				ACS Chem Biol 11: 3400-3411 (2016) Article DOI: 10.1021/acschembio.6b00709 BindingDB Entry DOI: 10.7270/Q2TD9W5M
Technical University of Munich					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Quaid-i-Azam University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin)				Eur J Med Chem 76: 193-244 (2014) Article DOI: 10.1016/j.ejmech.2014.02.005 BindingDB Entry DOI: 10.7270/Q26T0P8M
Quaid-i-Azam University Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant EphB2 (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant EphB2 (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant PDGFRalpha (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant PDGFRalpha (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR3 (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR3 (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR2 (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR2 (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR1 (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR1 (unknown origin) by cell-free assay				Bioorg Med Chem Lett 25: 2425-8 (2015) Article DOI: 10.1016/j.bmcl.2015.03.088 BindingDB Entry DOI: 10.7270/Q2KW5HRT
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 45: 5420-7 (2010) Article DOI: 10.1016/j.ejmech.2010.09.002 BindingDB Entry DOI: 10.7270/Q2TX3FMZ
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of VEGFR3				J Med Chem 55: 10797-822 (2012) Article DOI: 10.1021/jm301085w BindingDB Entry DOI: 10.7270/Q2BP03XZ
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of VEGFR2				J Med Chem 55: 10797-822 (2012) Article DOI: 10.1021/jm301085w BindingDB Entry DOI: 10.7270/Q2BP03XZ
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of VEGFR1				J Med Chem 55: 10797-822 (2012) Article DOI: 10.1021/jm301085w BindingDB Entry DOI: 10.7270/Q2BP03XZ
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.38	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
Nanjing University					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50331095 (CHEMBL1289494 \| Tivozanib \| US10464902, Tivozanib) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	7.2	25
Nanjing University					Assay Description VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...				Chem Biol Drug Des 86: 1323-9 (2015) Article DOI: 10.1111/cbdd.12596 BindingDB Entry DOI: 10.7270/Q2GB22TR
Nanjing University					More data for this Ligand-Target Pair