BDBM50331109 6-(9H-carbazol-9-yl)-N-hydroxyhexanamide::CHEMBL1290142::US8748451, 1
SMILES: ONC(=O)CCCCCn1c2ccccc2c2ccccc12
InChI Key: InChIKey=SOMDVJCUFVPZKM-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM50331109 (6-(9H-carbazol-9-yl)-N-hydroxyhexanamide | CHEMBL1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
The Board of Trustees of The University of Illinois US Patent | Assay Description HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC... | US Patent US8748451 (2014) BindingDB Entry DOI: 10.7270/Q26D5RPK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon/Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50331109 (6-(9H-carbazol-9-yl)-N-hydroxyhexanamide | CHEMBL1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Inhibition of recombinant human HDAC6 using Ac-RHKK(Ac)-ACC as substrate by fluorometric analysis | Bioorg Med Chem Lett 20: 7067-70 (2010) Article DOI: 10.1016/j.bmcl.2010.09.100 BindingDB Entry DOI: 10.7270/Q2FN16FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM50331109 (6-(9H-carbazol-9-yl)-N-hydroxyhexanamide | CHEMBL1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Inhibition of recombinant human HDAC1 using Ac-RHKK(Ac)-ACC as substrate by fluorometric analysis | Bioorg Med Chem Lett 20: 7067-70 (2010) Article DOI: 10.1016/j.bmcl.2010.09.100 BindingDB Entry DOI: 10.7270/Q2FN16FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cereblon/Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50331109 (6-(9H-carbazol-9-yl)-N-hydroxyhexanamide | CHEMBL1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 62 | n/a | n/a | n/a | n/a | 8.0 | 25 |
The Board of Trustees of The University of Illinois US Patent | Assay Description HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC... | US Patent US8748451 (2014) BindingDB Entry DOI: 10.7270/Q26D5RPK | |||||||||||
More data for this Ligand-Target Pair |