BDBM50331361 (S)-3'-chloro-4'-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)biphenyl-4-carbonitrile::CHEMBL1289406
SMILES: C[C@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)-c1ccc(cc1)C#N)C(F)(F)F
InChI Key: InChIKey=ZRLKRSYZYKQTQB-NRFANRHFSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50331361 ((S)-3'-chloro-4'-(4-(1,1,1-trifluoro-2-hydroxyprop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay | Bioorg Med Chem Lett 20: 7071-5 (2010) Article DOI: 10.1016/j.bmcl.2010.09.097 BindingDB Entry DOI: 10.7270/Q21G0MHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50331361 ((S)-3'-chloro-4'-(4-(1,1,1-trifluoro-2-hydroxyprop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of human 11beta-HSD1 by scintillation proximity assay | Bioorg Med Chem Lett 20: 7071-5 (2010) Article DOI: 10.1016/j.bmcl.2010.09.097 BindingDB Entry DOI: 10.7270/Q21G0MHX | |||||||||||
More data for this Ligand-Target Pair |