BDBM50331730 (+/-)-2-(9-(4-chlorobenzyl)-6-fluoro-8-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid::CHEMBL1289984
SMILES: CS(=O)(=O)c1cc(F)cc2c3CCCC(CC(O)=O)c3n(Cc3ccc(Cl)cc3)c12
InChI Key: InChIKey=USPFQIRXYBZUPX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostanoid DP receptor (Homo sapiens (Human)) | BDBM50331730 ((+/-)-2-(9-(4-chlorobenzyl)-6-fluoro-8-(methylsulf...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Antagonist activity at prostanoid DP1 receptor | Bioorg Med Chem Lett 20: 7462-5 (2010) Article DOI: 10.1016/j.bmcl.2010.10.018 BindingDB Entry DOI: 10.7270/Q2PZ5920 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid TP receptor (Homo sapiens (Human)) | BDBM50331730 ((+/-)-2-(9-(4-chlorobenzyl)-6-fluoro-8-(methylsulf...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Antagonist activity at prostanoid TP receptor | Bioorg Med Chem Lett 20: 7462-5 (2010) Article DOI: 10.1016/j.bmcl.2010.10.018 BindingDB Entry DOI: 10.7270/Q2PZ5920 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM50331730 ((+/-)-2-(9-(4-chlorobenzyl)-6-fluoro-8-(methylsulf...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Inc. Curated by ChEMBL | Assay Description Inhibition of PDE2 (unknown origin) | Bioorg Med Chem Lett 28: 1122-1126 (2018) Article DOI: 10.1016/j.bmcl.2018.01.039 BindingDB Entry DOI: 10.7270/Q2QV3Q4C | |||||||||||
More data for this Ligand-Target Pair |