BindingDB logo
myBDB logout

null

SMILES: FC(F)(F)[C@H]1C[C@H](Nc2c(cnn12)C(=O)OC12CC3CC(CC(C3)C1)C2)c1ccccc1

InChI Key: InChIKey=NYBHMQCIWADUPY-ZJJNMPENSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331947   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50331947
PNG
(1-Adamantyl-5-phenyl-7-(trifluoromethyl)-4,5,6,7-t...)
Show SMILES FC(F)(F)[C@H]1C[C@H](Nc2c(cnn12)C(=O)OC12CC3CC(CC(C3)C1)C2)c1ccccc1 |r,THB:21:20:17:23.22.24,21:22:19.20.25:17,24:22:19:25.16.17,24:16:19:23.21.22,15:16:19:23.21.22|
Show InChI InChI=1S/C24H26F3N3O2/c25-24(26,27)20-9-19(17-4-2-1-3-5-17)29-21-18(13-28-30(20)21)22(31)32-23-10-14-6-15(11-23)8-16(7-14)12-23/h1-5,13-16,19-20,29H,6-12H2/t14?,15?,16?,19-,20+,23?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 97n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting

Bioorg Med Chem 18: 8501-11 (2010)


Article DOI: 10.1016/j.bmc.2010.10.035
BindingDB Entry DOI: 10.7270/Q2CJ8DRD
More data for this
Ligand-Target Pair