BindingDB logo
myBDB logout

null

SMILES: FC(F)(F)[C@H]1C[C@H](Nc2c(CNC34CC5CC(CC(C5)C3)C4)cnn12)c1ccccc1

InChI Key: InChIKey=HLMSHPSRYXUUAT-HEKNWVKJSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331950   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50331950
PNG
(CHEMBL1289572 | N-{[5-Phenyl-7-(trifluoromethyl)-4...)
Show SMILES FC(F)(F)[C@H]1C[C@H](Nc2c(CNC34CC5CC(CC(C5)C3)C4)cnn12)c1ccccc1 |r,THB:17:16:13:19.18.20,17:18:15.16.21:13,20:18:15:21.12.13,20:12:15:19.17.18,11:12:15:19.17.18|
Show InChI InChI=1S/C24H29F3N4/c25-24(26,27)21-9-20(18-4-2-1-3-5-18)30-22-19(14-29-31(21)22)13-28-23-10-15-6-16(11-23)8-17(7-15)12-23/h1-5,14-17,20-21,28,30H,6-13H2/t15?,16?,17?,20-,21+,23?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting

Bioorg Med Chem 18: 8501-11 (2010)


Article DOI: 10.1016/j.bmc.2010.10.035
BindingDB Entry DOI: 10.7270/Q2CJ8DRD
More data for this
Ligand-Target Pair