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SMILES: C[C@H]1C[C@H](Nc2c(cnn12)C(=O)NC12CC3CC(CC(C3)C1)C2)c1ccccc1

InChI Key: InChIKey=NRRFDQQIPASXMH-OAGXWDRDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331960   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50331960
PNG
(CHEMBL1290106 | N-(1-Adamantyl)-7-methyl-5-phenyl-...)
Show SMILES C[C@H]1C[C@H](Nc2c(cnn12)C(=O)NC12CC3CC(CC(C3)C1)C2)c1ccccc1 |r,THB:18:17:14:20.19.21,18:19:16.17.22:14,21:19:16:22.13.14,21:13:16:20.18.19,12:13:16:20.18.19|
Show InChI InChI=1S/C24H30N4O/c1-15-7-21(19-5-3-2-4-6-19)26-22-20(14-25-28(15)22)23(29)27-24-11-16-8-17(12-24)10-18(9-16)13-24/h2-6,14-18,21,26H,7-13H2,1H3,(H,27,29)/t15-,16?,17?,18?,21-,24?/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting

Bioorg Med Chem 18: 8501-11 (2010)


Article DOI: 10.1016/j.bmc.2010.10.035
BindingDB Entry DOI: 10.7270/Q2CJ8DRD
More data for this
Ligand-Target Pair