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SMILES: C[C@@H]1C[C@H](c2ccccc2)n2ncc(C(=O)NC34CC5CC(CC(C5)C3)C4)c2N1

InChI Key: InChIKey=HVKXQZMYNPFSIT-DRFBCEGUSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331961   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50331961
PNG
(CHEMBL1290107 | N-(1-Adamantyl)-5-methyl-7-phenyl-...)
Show SMILES C[C@@H]1C[C@H](c2ccccc2)n2ncc(C(=O)NC34CC5CC(CC(C5)C3)C4)c2N1 |r,THB:22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23,16:17:20:24.22.23|
Show InChI InChI=1S/C24H30N4O/c1-15-7-21(19-5-3-2-4-6-19)28-22(26-15)20(14-25-28)23(29)27-24-11-16-8-17(12-24)10-18(9-16)13-24/h2-6,14-18,21,26H,7-13H2,1H3,(H,27,29)/t15-,16?,17?,18?,21-,24?/m1/s1
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting

Bioorg Med Chem 18: 8501-11 (2010)


Article DOI: 10.1016/j.bmc.2010.10.035
BindingDB Entry DOI: 10.7270/Q2CJ8DRD
More data for this
Ligand-Target Pair