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SMILES: FC(F)(F)[C@H]1CCNc2c(cnn12)C(=O)NC12CC3CC(CC(C3)C1)C2

InChI Key: InChIKey=ZRVBJXLSYBBOGL-HSVOFOGUSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331962   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50331962
PNG
(CHEMBL1290215 | N-(1-Adamantyl)-7-trifluoromethyl-...)
Show SMILES FC(F)(F)[C@H]1CCNc2c(cnn12)C(=O)NC12CC3CC(CC(C3)C1)C2 |r,THB:21:20:17:23.22.24,21:22:19.20.25:17,24:22:19:25.16.17,24:16:19:23.21.22,15:16:19:23.21.22|
Show InChI InChI=1S/C18H23F3N4O/c19-18(20,21)14-1-2-22-15-13(9-23-25(14)15)16(26)24-17-6-10-3-11(7-17)5-12(4-10)8-17/h9-12,14,22H,1-8H2,(H,24,26)/t10?,11?,12?,14-,17?/m1/s1
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Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting

Bioorg Med Chem 18: 8501-11 (2010)


Article DOI: 10.1016/j.bmc.2010.10.035
BindingDB Entry DOI: 10.7270/Q2CJ8DRD
More data for this
Ligand-Target Pair