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SMILES: O=C(NC12CC3CC(CC(C3)C1)C2)c1cnn2CC[C@H](Nc12)c1ccccc1

InChI Key: InChIKey=AXGLSWIKMWWPBI-SXYIGIQMSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331963   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50331963
PNG
(CHEMBL1290216 | N-(1-Adamantyl)-5-phenyl-4,5,6,7-t...)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1cnn2CC[C@H](Nc12)c1ccccc1 |r,THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9,2:3:6:10.8.9|
Show InChI InChI=1S/C23H28N4O/c28-22(26-23-11-15-8-16(12-23)10-17(9-15)13-23)19-14-24-27-7-6-20(25-21(19)27)18-4-2-1-3-5-18/h1-5,14-17,20,25H,6-13H2,(H,26,28)/t15?,16?,17?,20-,23?/m0/s1
PDB

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 5.30E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting

Bioorg Med Chem 18: 8501-11 (2010)


Article DOI: 10.1016/j.bmc.2010.10.035
BindingDB Entry DOI: 10.7270/Q2CJ8DRD
More data for this
Ligand-Target Pair